Players often need to take advantage of the darkness to stay undetected for an entire mission. Gameplay is in the third person, and involves a lot stealth play, similar to the Splinter Cell and Metal Gear Solid series, with some platform, exploration and combat-style elements too. It's up to John and his team to hunt down the Prime Walker and clear the city of the vampire infestation.
The player controls John Lloyd, an agent on such a team, sent in to discover the whereabouts of an advance recon team that has gone missing in a city swarming with Nightwalkers. The American Information Bureau has created a team to hunt down and destroy Nightwalkers - modern day vampires.